How to get started in GUI Programming?

[Luis M. Gonzalez]

IMHO, the easier alternative for building GUI apps with Python is
PythonCard.
It is based on wxWindows, and it lets you build gui apps by dragging
and dropping widgets on a form, just like VB or Delphi. It is very high
level and very easy to learn and use.

http://pythoncard.sourceforge.net/

Another alternative, also based in wxWindows, is Boa Constructor, but I
wouldn't recomend it over Pythoncard.

Good luck!
Luis