Considering migrating to Python from Visual Basic 6 for engineering applications

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I am mostly getting positive feedback for Python.

It seems Python is used more for web based applications. Is it equally fine for creating stand-alone *.exe's? Can the same code be compiled to run on Linux or Android or web-based?

Is it possible to create GUI elements with a good IDE? Can they be defined like in Visual Basic with given sizes, fonts, visible/invisible, etc.?

Is it easy to do matrix operations in Python? Or do I need to write subroutines like in Visual Basic?

Could someone kindly tell me advantages and disadvantages of Python? Or any better options? I have like 40-50 VB Forms and may be around 20000 lines of code. It will be a task to learn a new language and translate/re-write that code.

Thanks for your responses.