using python in web applications

[Laurent]

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For a serious web based MMO you'd rather stick to low level and forget about bloated Object Relational Mapping java-like layered kind of frameworks that are made for Rapid Applications Development, not for efficiency.
[/troll]

"Eve Online", a well known MMORPG was developped with stackless python : http://highscalability.com/eve-online-architecture

You mentioned nginx so I can tell you I personally use Linux + nginx + mongodb (pymongo) + Python 3 version of cherrypy (with Mako templates) and it's working fine after some tuning.