Python app dev tools for Gnome?

[kj]

There's a zillion utility apps that I've had kicking around in my
head for years, but I've never implemented because I absolutely
hate GUI programming.

But I'm increasingly impressed by the quality, stability, and sheer
number, of Gnome apps that I keep coming across that use Python
under the hood.

This gives me hope that maybe programming GUI Python apps for Gnome
these days is no longer the traumatizing experience it used to be
when I last tried it.

Can someone recommend some good tools to speed up the development
of Python apps[1] for Gnome?  E.g. is there anything like Xcode
for Gnome+Python?

TIA!

~kj

[1] Needless to say, when I write "apps" I mean full-blown GUI
apps: windows, menus, events, threads, clickable icon, the whole
ball of wax.  As opposed to cli apps, panel widgets, etc.