Have you ever considered of mousing ambidextrously?

[WangQiang]

I'm also a programmer, as working in front of computer day and day, my
right hand is so tired and ached. So I tried to mouse in both hands. I
find that it is really an efficient way to release pains. At first I
switched the mouse buttons in windows control panel, but it taked me
several steps to finish it, and I can't flip the cursor, so I maked a
utility. With it I can switch mouse buttons and flip the cursor
immediately by pressing a hotkey. I gave it a name: "Ambidexter Mouse",
do you want to have a try: www.ambidexter-mouse.com