Zope/Plone - Is it the right solution?

[Michele Simionato]

It depends on how much time do you want to spend fighting with the
framework.
I usually do not recommend Zope, unless you want to make a career as a
Zope
consultant. If you have to interact with a relational database, your
life with Zope
may be hard: http://www.jrandolph.com/blog/?p=23

For easy of use nothing beats CherryPy, but I am not sure how stable it
is.
Quixote is nice and small, and pretty easy to use too.
Many likes Django and TurboGears.

Zope and Twisted are for people who have a lot of time to invest.

      Michele Simionato