How to get started in GUI Programming?

[Jonathan Gardner]

I would argue with your assertion that either TKinter of PyGTK are the
best. There are several other good alternatives, including wxPython and
PyQt, which are very comparable, if not better.

I would strongly suggest starting with PyQt. It's my personal favorite.
I wrote a short tutorial on the Python Wiki.

http://wiki.python.org/moin/JonathanGardnerPyQtTutorial

I find that the Qt API is a lot simpler than the alternatives. Plus, it
has great documentation.