FWIW, I had a similar problem but was not using INNO; just py2exe, COM, anygui, and easygui. My problem was fixed when I included PythonCOM22.dll in the distribution. Python 2.2.2 (#37, Oct 14 2002, 17:02:34) [MSC 32 bit (Intel)] on win32 py2exe version 0.4.0