I try to sendmessage across process to simulate mouse click but didn't work. wnd = win32ui.FindWindow(None,"PythonWin") wnd.SetForegroundWindow() win32api.SetCursorPos(100,100) # somewhere in windows wnd.SendMessage(win32con.WM_LBUTTONDOWN,0,0) wnd.SendMessage(win32con.WM_LBUTTONUP,0,0) Any ideas?