Mixed Python/C debugging

[Skip Montanaro]

After at least ten years away from Python's run-time interpreter &
byte code compiler, I'm getting set to familiarize myself with that
again. This will, I think, entail debugging a mixed Python/C
environment. I'm an Emacs user and am aware that GDB since 7.0 has
support for debugging at the Python code level. Is Emacs+GDB my best
bet? Are there any Python IDEs which support C-level breakpoints and
debugging?

Thanks,

Skip