Launching a Script on the Linux Platform

[Wildman]

What is the best approach for launching a Python GUI program
on a Linux platform.  The program will be distributed in .deb
format.  So the .deb will contain a menu file as well as a
.desktop file.  The post install script will update the system
menu.

My question is how should the program be executed?  Here are
two choices for the "command=" entry in the menu file...

command="/path/to/program.py"

In this case the hash-bang would have to be included in the
program script... #!/usr/bin/env python3

The other choice is this...

command="python3 /path/to/program.py"

(Of course, the Exec command in the .desktop file should match.)

Is one method better than the other or does it acutally matter?

-- 
<Wildman> GNU/Linux user #557453
"There are only 10 types of people in the world...
those who understand Binary and those who don't."
  -Spike