How to pass Python command line options (vs arguments) when running script directly vs via Python interpreter?

[Malcolm Greene]

> If you run the script directly, by entering >script.py or clicking a script icon or name in File Explorer, it runs python without python options *other than those specified in environmental variables*.

Understood. I thought there might have been a way to pass Python option values via a single environment variable (something like PYTHONOPTIONS)  vs individual environment variables.

Thank you
Malcolm