Exploring Python for next desktop GUI Project

[CM]

On Thursday, July 24, 2014 11:57:22 AM UTC-4, Noble Bell wrote:
> I am exploring the idea of creating my next desktop GUI project in Python and would like a little advice from you folks about a couple of requirements.
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> My requirements will be:
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> 1. Needs to be portable across platforms with native LAF (Windows,Linux,OSX)

wxPython.

> 2. Python 2 or 3? Which will serve me better in the future?

Long term (7 years), 3.  Middle-term, either, though you may need a library that is not yet ported to 3.  wxPython Phoenix is available in a not-yet-completely-done way and people are reporting using it to make function GUIs. It is not done yet, though, and some/all of the wx.lib widgets are not available in it. 

If I were you I'd go with Python 2.7 and wxPython 2.9.x, but other options are reasonable too.
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> Thanks in advance.
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> Noble