I am fed up with Python GUI toolkits...

[Andrew Berg]

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There's PyGUI, which, at a glance, fits whit what you want. Looks like
it uses OpenGL and native GUI facilities.
http://www.cosc.canterbury.ac.nz/greg.ewing/python_gui/

It has quite a few external dependencies, though (different dependencies
for each platform, so it requires a lot to be cross-platform).

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