There is a macpython list that you can consult at http://www.nabble.com/Python---pythonmac-sig-f2970.html. When you search for your problem http://www.nabble.com/forum/Search.jtp?forum=2970&local=y&query=mysqldb you have the solution http://www.nickshanny.com/2007/10/os-x-105-python-and-mysqldb.html