How is GUI programming in Python?

[CM]

On Apr 11, 3:29 pm, Rune Strand <rune.str... at gmail.com> wrote:
> On Apr 11, 8:35 pm, Steve Holden <st... at holdenweb.com> wrote:
>
> > wxDesigner.
>
> Yeah, but it's like Heron of Alexandria's Aeolipile compared to the
> steam engine of James Watt.
>
> IMHO, GUI with Python is pain, pain and utter pain. Even boring and
> meaningless pain.

What do you prefer, then, to do GUI with?  And why?