Python for .NET and IronPython

[James]

IronPython is good if you want to bring in Python into a .NET world.

Python for .NET is good if you want to bring in .NET into a Python
world.

As for your learning concerns, there need be none. There is really
nothing to learn extra for the integration. They just work. Once you
learn the .NET framework and Python, there isn't much to know
additionally.

While you are on topic, check out Boo. It is not the same as the ones
you mentioned but you might find it interesting and useful while
working with .NET if you have Python tastes.