To be honest, this is a pretty open-ended question. Are there specific issues (SQL injection/security, minimizing db connections, simplest code, etc, your'e concerned with?) To be more honest, googline "Python vs. PHP" raises lots of hits http://wiki.w4py.org/pythonvsphp.html http://www.redcor.ch/wikis/semi_intern/BasicReferenceOfMoreLanguages