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Have you tried PythonCard?
It lets you visually build user graphical user interfaces (based on
wxPython) in a Delphi-like way.
It is very, very easy to use and very simple.
The only downside is that, at least in its current version, there's no
data grid control implemented, so if you work with databases, this is
a little shortcoming.
For any other purpose, it's just great. 
Give it a try ... http://pythoncard.sourceforge.net

And don't forget to watch the evolution of IronPython (which was
recently released as pre-alpha). It is a python implementation for the
.NET framework and Mono (linux), which is going to be the next big
thing in python.
I was playing with it, and even without a graphic builder, it's very
easy to come up with a nice GUI written by hand..