win32com.client.Dispatch("WScript.Shell")

[Shawn Wheatley]

>pywintypes.com_error (-2147221008, 'CoInitialize has not been called.', 
>None, None) 

You may be able to find more info on your error by searching MSDN for
this number as hex:

>>> hex(-2147221008)
'0x800401f0'

Shawn