These are the RPM's I used: http://prdownloads.sourceforge.net/wxpython/wxPythonGTK-py2.3-2.4.2.4-1.i386.rpm http://prdownloads.sourceforge.net/wxwindows/wxGTK-2.4.2-1.i386.rpm Maybe you tried the static wxWindows RPM? What did rpm say when it baulked - did you use 'rpm -Uvh' as root?