Smallest Standalone Distributable Possible?

[Dry Ice]

What is... The Smallest Standalone Distributable Possible?

Please assume the following.

The goal is RAD of a small-medium sized application in Python.
The application will be standalone, i.e.,
    it will install into a single folder,
    it will install NOTHING anywhere else
       (except a startup icon),
    it will not touch the registry,
    and it will require the existance or
       installation of nothing outside its folder.

Is this possible in Python?

If so, how large might the distributable package be
and what might it contain, at minimum?